The Portsmouth Company Cotton Mills Counting House is a historic industrial building at Main and Liberty Streets in South Berwick, Maine. Built in 1832, it is the only surviving element of the Portsmouth Company Cotton Mill, one of several textile mills operating in South Berwick in the 19th century. It is now home to the Old Berwick Historical Society, which operates it as the Counting House Museum. The building was listed on the National Register of Historic Places in 1975.