Zadock Pratt House, also known as the Zadock Pratt Museum, is a historic home located at Prattsville in Greene County, New York. It was originally built in 1828 as a two-story, five-bay Federal style residence. It was substantially altered about 1856 with the addition of numerous architectural details reminiscent of the romantic, picturesque tastes in mid-19th century America. It is a frame structure constructed of massive hemlock posts and beams over a stone foundation. It features broadly projecting eaves and a two-story portico supported by octagonal columns. Also on the property is the original well. It was the home of Zadock Pratt (1790–1871), founder of Prattsville. It has operated as a house museum since 1959. In 2011 the ground floor was damaged heavily by Hurricane Irene.