The fire started on a riverboat along the Mississippi River where Cherry St. reached the river. Cherry St. no longer runs to the river but the site here is the approximate location where it did.
The St. Louis Fire of 1849 was a devastating fire that occurred on May 17, 1849 and destroyed a significant part of St. Louis, Missouri and many of the steamboats using the Mississippi River and Missouri River. This was the first fire in United States history in which it is known that a firefighter was killed in the line of duty. Captain Thomas B. Targee was killed while trying to blast a fire break.