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New England Compounding Center meningitis outbreak

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Description


New England Compounding Center meningitis outbreak

In October 2012, an outbreak of fungal meningitis was reported in the United States. The U.S. Centers for Disease Control and Prevention (CDC) traced the outbreak to fungal contamination in three lots of medication used for epidural steroid injections. The medication was packaged and marketed by the New England Compounding Center (NECC), a compounding pharmacy in Framingham, Massachusetts. Doses from these three lots had been distributed to 75 medical facilities in 23 states, and doses had been administered to approximately 14,000 patients after May 21 and before September 24, 2012. Patients began reporting symptoms in late August, but because of the unusual nature of the infection, clinicians did not begin to realize that the cases had a common cause until late September. Infections other than meningitis were also associated with this outbreak, which spanned 19 states. As of January 14, 2013 (2013-01-14), 375 of the 678 reported cases of fungal infection included meningitis, and some patients had multiple symptoms: 44 patients had died.[1] In November 2012, it was reported that some patients recovering from meningitis were experiencing secondary infections at the injection site.[2] Although no cases of infection are reported to be associated with any other lots of medication, all lots of all medications distributed by NECC were recalled in separate actions by NECC and regulators. Subsequent analysis identified some contamination in other lots.

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