The Astor Place Riot occurred on May 10, 1849 at the now-demolished Astor Opera House in Manhattan, New York City and left at least 25 dead and more than 120 injured.[2] It was the deadliest to that date of a number of civic disturbances in New York City which generally pitted immigrants and nativists against each other, or together against the upper classes who controlled the city's police and the state militia.