The Edwin DeVries Vanderhoop Homestead, is an historic house at 35 South Road, Aquinnah, Massachusetts, USA. The c. 1890s house is the first built by a member of the Vanderhoop family, which is prominent in the town politics of Aquinnah and in the tribal organization of the Wampanoag Tribe of Gay Head. The house was listed on the National Register of Historic Places in 2006.