Huai Kha Khaeng Wildlife Sanctuary (Thai: เขตรักษาพันธุ์สัตว์ป่าห้วยขาแข้ง) is a protected area in Thailand. It is located in the Dawna Range, Kanchanaburi, Tak and Uthai Thani Provinces. It was declared a World Heritage Site Site by the United Nations in 1991, together with the adjoining Thungyai Naresuan Wildlife Sanctuary. Huai Kha Khaeng stretches over an area of 257,464 ha.