Tsimanampetsotsa National Park also spelt Tsimanampetsotse, and known as Tsimanampetsotsa Nature Reserve is a national Park in the region Atsimo-Andrefana in Madagascar. It lies on the southwest coast, south of Toliara. It contains Lake Tsimanampetsotsa, an important wetland and a Ramsar site. The Ramsar site has a total area of 456 km (176 sq mi) while the surface of the lake is much smaller.